130. Bacteremia among patients with cancer in a Latinamerican country, clinical and molecular data

Abstract Background Infections are common complications in patients with cancer. Data on antimicrobial resistance is important to guide empirical therapy. However, rates varies among different regions and countries and, general, higher Latin America. There limited data from these this region. The aim of work determine the frequency antibiotic susceptibility profiles, as well identify most frequent genes related resistance, microorganisms implicated bacteremia diagnosed cancer Methods A cross-sectional multicenter study conducted six hospitals Colombia. An active laboratory search was carried out for adult bacteremia. obtained electronic medical records, according microorganisms, molecular tests were performed a standardized way methicillin-resistance, extended spectrum beta lactamases carbapenemases. In addition, an exploratory multivariate analysis using logistic regression method predict mortality Results 195 6 included study. clinical variables described Table 1. Gram-negative bacteria more their high. found resistant bacterial isolates 2; main identified blaCTX-M blaKPC, generating ESLB-type beta-lactamases carbapenemases, respectively. 30 day-mortality 26%, which similar other studies. Multivariate showed that adequate treatment (OR: 0.26 (95%CI 0.1-0.63)) number platelets (per 10,000, OR: 0.97 0.94-0.99)) associated survival. Mortality palliative care (OR 3.51 1.05-12.04)). Conclusion bacilli frequently high level identified. what has been world. Appropriate prompt patient would improve outcomes. Disclosures Jorge A. Cortés, MD, pfizer: Grant/Research Support Carlos Saavedra-Trujillo, pfizer merck: Support.